Sulforaphane dosage in clinical trails and finished products
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Sulforaphane (SFN), a natural substance with the strongest anticancer activity, has been used in many clinical studies. Some studies used glucoraphanin (GRA, the precursor of SFN) and some used broccoli sprouts, so the doses forms were not uniform. Although dose forms and study populations and endpoints are different across the selected trials, a pattern emerges to show that clinical outcomes are achievable in conditions such as asthma with daily SFN doses of around 18 mg daily and from 27 to 40 mg in type 2 diabetes. A lower SFN dose of around 9-14 mg daily yielded a positive outcome in the autism study by Singh et al., whereas H. pylori control was effective with a higher dose of 30 mg SFN daily. Of the available trials, the prostatespecific antigen (PSA) doubling time after radical prostatectomy selected the higher 60 mg daily dose. According to statistics, taking 20-40mg of SFN every day can achieve a certain effect in clinical practice.
Sulforaphane dosage from lowest to highest in selected clinical trials
The analysis of 24 kinds of broccoli products on the market shows that the active ingredient in most products is GRA, and the content varies greatly, and the actual SFN content of the products also varies greatly. Among them, there are only 5 products with SFN content of 20-40mg, accounting for less than 20%. Most products contain less than 10mg of SFN. At present, it seems that improving the conversion rate of GRA is the key.
The SFN content of broccoli products
Actual SFN content(mg / serving dose)
Product number
Percentage(%)
<1
8
30.8%
1-10
6
23.1%
10-20
7
26.9%
20-40
5
19.2%
Sanherb recommends that the daily dose of SFN for general food is 10-20mg, nutritional supplements for sub-healthy people is 20-30mg, nutritional supplements providing nutritional support for patients is 30-40mg. The average conversion rate of pure GRA in the gastrointestinal tract is only 10%. With a conversion rate of up to 62%, Sanbroc® GRA Plus helps you increase the SFN content in your product. Moreover, the conversion rate of SFN reached 84% in the tablet candy processed with the formula of Sanherb.
The recommended daily dose of SFN and the corresponding dose of GRA
Daily dose of 100% SFN (mg)
Daily dose of 13% GRA (mg)
Daily dose of Sanbroc® 13% GRA Plus (mg)
Daily dose of Sanbroc® 13% GRA Plus with Sanherb’s formula(mg)
10
1920
310
230
20
3840
620
460
30
5760
930
690
40
7680
1240
920
References（obtained by email: info@sanherb.com）
Houghton C A . Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease[J]. Oxidative medicine and, cellular longevity, 2019, 2019(8):1-27.
