Effects of Broccoli Seed Extract on Diabetes

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• Introduction
  Diabetes, as a chronic multiple disease, has become a key public health issue of global concern. Diabetes and its related complications not only seriously endanger the quality of life and life expectancy of patients, but also impose a heavy economic burden on the family and society. Type 2 diabetes (T2DM) is the most common type of diabetes, accounting for about 90% of the total number of diabetes, so the prevention and treatments of type 2 diabetes and its complications are very important. Studies have confirmed that sulforaphane can prevent and delay diabetes and its complicated nephropathy and cardiomyopathy. Sulforaphane can effectively reduce the sugar production in liver cancer cells and liver cells. Clinical studies have also found that broccoli sprout extract can effectively reduce fasting blood glucose and glycosylated hemoglobin levels in obese type 2 diabetic patients with poor blood glucose control ability.
  Researches
  Studies have confirmed that sulforaphane can prevent and delay diabetes and its complicated nephropathy and cardiomyopathy. In 2012, Iranian scholars conducted a clinical trial with sulforaphane broccoli sprout powder. 81 patients with type 2 diabetes were randomly divided into 3 groups, taking 10g, 5g and placebo daily for 4 weeks, respectively. It was found that taking 10g of broccoli sprouts powder daily can improve insulin resistance in patients with type 2 diabetes. 
  In 2017, Professor Anders Rosengren from the Diabetes Research Center of Lund University in Sweden discovered that sulforaphane can inhibit the production of glucose in liver cells. A dose equivalent to 150 mmol sulforaphane once a day was taken once a day while continuing to take metformin, a hypoglycemic drug for 12 weeks, it can effectively reduce the fasting blood glucose and HbA1c (HbA1c) levels of T2D patients with obesity and poor blood glucose control. Related research is published in Science Translational Medicine. 
  A clinical trial in Japan confirmed that daily intake of sulforaphane-rich broccoli sprouts (25g/day) for 2 months significantly reduced the body weight, body mass index and waist circumference of healthy subjects, and reduced Glycated hemoglobin, diastolic blood pressure and total cholesterol levels. Oral broccoli sprouts also reduced the levels of serum AGEs (advanced glycation endproducts) and the ratio of AGEs to soluble RAGE (receptor for advanced glycation endproducts, sRAGE) in these subjects, and increased their awareness of eating healthy food.